Cellular Predictors of MTX Response MTX polyglutamates have been investigated in JIA and thus far appear not to be correlated to drug response, as has been reported in rheumatoid arthritis.
Higher MTX-PG concentrations were associated with improved disease activity among patients with RA receiving MTX therapy, though they were also linked to hepatotoxicity.
Once inside red blood cells, the drug can assume up to five different forms, which are known as MTXGlu1-5 (MTX polyglutamates) These can be measured inside red blood cells and are thought to be ...