A groundbreaking study has identified a naturally occurring ligand derived from vitamin B6 that can activate immune cells to ...

The majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic ...

TCR immunotherapy is emerging as a promising, targeted approach for treating solid tumours and other indications.

T cell-based immunotherapies including immune checkpoint blockade and chimeric antigen receptor T cells can induce durable responses in patients with cancer. However, clinical efficacy is limited due ...

and it is thought that the likely candidate genes predisposing patients to this category of disease are those of the major histocompatibility complex. Genes that affect the immune, inflammatory ...

The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell ...