BCL-2 inhibitors, such as venetoclax (Venclexta) work by targeting the BCL-2 protein, which plays a key role in preventing apoptosis, or programmed cell death. According to John Seymour, MD, ...

The five-drug combination decreased the levels of BCL-2, BCL-xL and MCL-1, suggesting its potential ... Enhanced activation of apoptosis was observed in leukemia patient-derived cell samples ...