Indomethacin has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of indomethacin, like that of other NSAIDs, is not completely understood but involves inhibition ...

Indomethacin, ibuprofen, and gentamicin are commonly administered to neonates between 24 and 28 wk gestation when glomerulogenesis is still occurring. Indomethacin is known to cause renal failure ...

The researchers found that PGD2 primarily activates DP2 through the Gαi signaling pathway, while indomethacin preferentially activates the β-arrestin pathway. This signaling bias was further ...