TFIIH is also a large (10 subunit, 0.5MDa) and structurally dynamic protein complex. Like Mediator and TFIID, TFIIH is required for pol II transcription, genome-wide. Notably, Mediator, TFIID, and ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Mediator is a 26-subunit complex that regulates RNA polymerase II (RNAPII) transcription genome-wide (Richter et al. 2022). Mediator is recruited to specific genomic loci through interactions with ...