The Institute for Behavioral Genetics has the world's most complete collection of mouse strains that have been engineered to express mutations in nicotinic cholinergic receptor (nAChR) subunit genes.

What kinds of mutations create "lethal genes," and how are they passed on? Lethal genes can be recessive, as in the aforementioned mouse experiments. Lethal genes can also be dominant, conditional ...

In attempting to engineer a genetic mouse model for a human disorder, for example, it is important to know what kind of mutation causes the disease (for example, is the disease null, hypomorphic ...

We generated a mouse model by creating a mutation that truncates the protein post–amino acid 308. Male Mecp2308 mice appear normal up to six weeks of age, when they develop tremors, seizures, ...

More information: Cara Nasello et al, Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice, Proceedings of the ...