Given that extracellular ATP through P2X7 receptor constitutes a neuron-to-microglia alarm signal implicated in ALS, and that P2X7 affects autophagy in immune cells, we have investigated if autophagy ...

Linh Le, Ph.D., currently a Research Scientist, found the expected response from microglia to PLX3397 in male mice—it blocked the receptor that signals microglial survival and depleted the ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

We do not yet know why the microglia are acting differently in the two sexes. I think we'd like to understand how the signaling through this receptor is regulated in different conditions ...

The authors sought to investigate the role of microglia in AGS by first developing bone-marrow-derived progenitors in vitro that carry the estrogen-regulated (ER) Hoxb8 cassette, allowing them to ...

First author Linh Le, PhD (‘24), currently a Research Scientist, SetPoint Medical Corp, was a graduate student in the Majewska Lab when she found the expected response from microglia to PLX3397 in ...

Linh Le, PhD (‘24), currently a Research Scientist, SetPoint Medical Corp was a graduate student in the Majewska Lab and is first author of this study, found the expected response from microglia to ...