Mutation of the MMR genes cause alterations in the length of simple repetitive genomic sequences (microsatellite instability, MSI). MSI analysis has been a useful tool for HNPCC screening and for ...

Where Lynch syndrome is suspected, screening by either immunohistochemical analysis of tumor MMR protein expression or by tumor genotyping for microsatellite instability is usually undertaken ...

Breakthrough Therapy designation by the FDA is intended to speed up the development and review of drugs that ... repair machinery and high microsatellite instability (dMMR/MSI-H), abnormalities ...

The EC has approved Opdivo plus Yervoy for the first-line treatment of adult patients with microsatellite instability–high ... by Blinded Independent Central Review. Also, the safety profile ...

as well as its efficacy in microsatellite instability-high (MSI-H) CRC. Additionally, one presentation will feature BOT/BAL and invariant natural killer T cells (iNKTs) in patients with refractory ...