Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca2+ signaling.
3 endothelial cells, we conducted cell-based screening to identify compounds that inhibit the mitochondrial ROS production induced by elevated extracellular glucose. We have tested a focused ...
a professor of molecular and cellular biology at the University of California, Davis, who was not involved in the work, wrote in an e-mail to The Scientist. “This is a straightforward and clear story, ...
Paroxetine reduced hyperglycemia-induced mitochondrial ROS formation, mitochondrial protein oxidation, and mitochondrial and nuclear DNA damage, without interfering with mitochondrial electron ...