Inactivating germ line mutations in the neurofibromatosis type 1 (NF1) gene are responsible for the many manifestations of this disease that range from intellectual deficits, to autism, to bone ...

This study reveals the key role of microglia, brain’s immune cells, in brain metastases progression and identifies a strategy ...

今天发表在《Cancer Cell》杂志上的这项研究表明，在临床前小鼠模型中，可以操纵小胶质细胞（大脑中的一种常驻免疫细胞）来减少脑转移瘤的生长并增强免疫治疗反应。由Berta Sánchez-Laorden领导的实验室的研究人员发现，小胶质细胞可以从促进肿瘤的状态重新编程为加强抗肿瘤反应的状态。Berta Sánchez-Laorden是印第安纳大学细胞发育和疾病可塑性小组的一部分。

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas ...

The next mutation paves the way for the development of an even more aggressive cancer. At this point the tumor is still contained.

Metastasis is now underway, as tumor cells from the original cancer growth travel throughout the body. Most of these cells will die soon after entering the blood or lymph circulation.