"Nucleoside analogs are among the most important molecules to the advancement of modern medicine," says Michael Meanwell, assistant professor in the Department of Chemistry and corresponding ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

Antiviral nucleoside analogues and prodrug strategies are crucial in the development of effective treatments for viral infections. Nucleoside analogues mimic the building blocks of DNA and RNA ...

A number of nucleoside analogues which were expected to exhibit antibiotic activity were inactive because they are not substrates for the enzymes that phosphorylate nucleosides. Nucleotides themselves ...

In addition, some nucleoside analogue reverse transcriptase inhibitors (most notably zalcitabine and stavudine and, to a lesser extent, didanosine) represent an important contributor to peripheral ...

This combination regimen, added to these patients receiving ongoing nucleoside analogue therapy, showed that a good amount of them achieved a functional cure. I will be going over this data below ...

Generally, the dual NRTI backbone treatment of combination with a non-NRTI (NNRTI) or protease inhibitor (PI) should comprise a cytidine analogue (lamivudine, emtricitabine) and a thymidine ...