p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

Tobacco-related cancers, including those associated with ETS, often show the same p53 mutations associated with aflatoxin exposure. The role of ammonia in neutralizing aflatoxin contamination is ...

Researchers in Michael Sigals lab at the Max Delbruck Center and Charite - Universitatsmedizin Berlin have discovered the ...

a group of researchers investigated the role of Fas Cell Surface Death Receptor (FAS) in regulating Tumor Protein p53 (p53) expression in adipocytes and its impact on energy metabolism ...

These mechanisms, including those involving the tumor suppressor protein p53, are widely studied due to their critical role ...

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfill its task. Until now, researchers have assumed that the process is the same with all mutation types.