In contrast to PARP1 and PARP2, neither PARP10 nor the predicted PARP-family mART enzymes are thought to ... length and with a branched, complex structure, the mono-ADP-ribosylation of specific ...

PARP-1 is an enzyme directly involved in repairing single-stranded DNA breaks. It senses single-stranded DNA breaks through a zinc-finger DNA-binding domain, binds to the sites of breaks and ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are promising cancer treatments because they block a cell’s ability to repair DNA damage. Four PARPis are currently approved for use in the ...

PARP inhibitors target the DDR PARP enzymes support single strand break repair and prevent formation of DNA double strand breaks (DSBs) during replication. Repair of these DSBs requires homologous ...