The PINK1 protein product has been implicated in several functions, mostly aimed at protecting neuronal cells against different types of stress. Growing evidence indicates that PINK1 interplays ...

Several lines of evidence indicate that PINK1 can protect cells from different types of stress, including proteasomal inhibition, oxidative stress, mitochondrial blockers and apoptotic inducers.

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...