use of immunologic bench assays to replace bioassays involving animals, use of computer software to model the pharmacokinetics of drugs in place of animal studies. Unfortunately, it is not very common ...

Background: There is strong experimental evidence of a neuroprotective effect of melatonin in immature animals. However, pharmacokinetic (PK) data on melatonin in preterm infants is lacking.

Healthy animals are employed to generate time-dependent concentration profiles for calculating ... This information helps to understand drug distribution in the body as well as accumulation in a ...