b Patients taking 25-50 mg once daily should take one supplemental pregabalin dose of 50 or 75 mg after hemodialysis. c Patients taking 75 mg once daily should take one supplemental pregabalin ...

Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of ...

Obermann and colleagues have recently reported that pregabalin, a new drug that reduces release of excitatory neurotransmitters, shows promise as a treatment for TN. Their prospective, open-label ...