To develop a small-molecule drug, researchers spend years ... called structure-based drug design. The 3-D structure of many proteins remained unavailable, and many important proteins could not ...

Predicting a protein's structure from its amino acid sequence ... A 4 Å model will indicate what residues are on the same side of the molecule and could help in planning experiments.

The way in which the chain of amino acid units in a protein molecule is coiled and folded in space has been worked out for the first time. The protein is myoglobin, the molecule of which contains ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

Researchers led by Uljana Kravčenko and her colleagues in the lab of Professor Misha Kudryashev, Group Leader of the In Situ ...

Scientists still needed to figure out this molecule's structure to be sure, and to understand how it worked. In 1948, Linus Pauling discovered that many proteins take the shape of an alpha helix ...

These DZBB assemblies serve as a versatile foundation for molecular ... for synthesizing proteins in cells. This evolutionary ...

The new Dogma meets Thomas Kuhn’s definition of a paradigm shift. The DNA/RNA Dogma is sufficiently unprecedented to attract ...

Deoxyribonucleic acid (DNA) is the information-carrying molecule found in all living ... is the instructions that the cell uses to make proteins. Proteins play a big part in determining the ...

Researchers have found an ancient protein fold that might explain how life’s basic building blocks became the complex systems ...

AlphaFold 3 can predict protein structures and interactions, and now researchers around the world can use it freely.