Applicants are anticipated to have a strong background in biological NMR spectroscopy and general biophysical understanding of macromolecules. A proficiency in biochemistry and protein expression and ...

While this is undoubtedly true of the many beautiful structures that have been produced both by X-ray crystallography and more recently by NMR spectroscopy ... the path for protein engineering ...

Structure determination by NMR typically requires a protein concentration of 0.5 mM or greater, stable for several days at the desired temperature, usually 20-40 o C. Proteins and peptides should be ...

Our group applies structural (cryo-EM, x-ray crystallography and NMR), biochemical and biophysical methods together with functional studies to investigate macromolecular-mediated recognition, ...

The Varian INOVA 500 is the workhorse for high-field NMR in the facility. The console is equipped with one high-band (1H/19F) channel and two broadband-band channels. The instrument is normally ...

Predicting how a protein folds into a ... the 3-D structures are worked out in the lab by biologists using traditional techniques like X-ray crystallography and NMR spectroscopy, which determine ...

Cradle is one of these, focused on protein design — and it just raised ... it’s still a biotech company. “We have a laboratory in Amsterdam where we use to A/B test on many different types ...