In principle, this can be assessed by measuring the distinctive firing patterns, known as complex spikes, generated by Purkinje cells — the neurons that generate the output of the cerebellum.

Degeneration of Purkinje cells is associated ... including autism spectrum disorder and cerebellar ataxia, a condition that affects muscle movement. Other neurons within the organoids-;both ...

Unlike other brain regions, the cerebellum has multiple progenitor zones (Leto, 2015; Joyner & Bayin, 2022)(Fig. 1C-E). The ventricular zone gives rise to all the GABAergic (inhibitory) cells ...

Specifically, the research team found that a hormone, asprosin, crosses from the periphery into the brain to activate Purkinje neurons in the cerebellum. This leads to an enhanced drive to seek ...

Although such predictions are thought to be stored as associative motor memories in the cerebellum, the circuit mechanisms by which they form and are acted upon remain unclear. Correlates of such ...

Neurons can shuttle ions across their membrane through channels and pumps, which changes the voltage of the membrane. Fast firing Purkinje neurons have a higher membrane voltage than slow firing ...

We have gone a step further by building circuits that model spiking neurons with history dependent components ... and biophysical modeling to understand the computational function of changes in ...

The Orengo lab as generated a novel conditional mouse model for spinal cerebellar ataxia, type 1 (SCA1 ... To date we have used Cre drivers to allow for expression of the toxic protein in only motor ...