Finally, based on these in vitro findings, the authors investigated whether vitamin B3 could be used instead of G-CSF as a treatment to boost neutrophil numbers in neutropenic subjects.

Filgrastim is a lineage-specific colonystimulating factor (CSF), mainly affecting neutrophils. In addition to enhancing neutrophil recovery, filgrastim may also enhance neutrophil functional activity.

Outcomes measured to evaluate CSF efficacy include the incidence of febrile neutropenia, neutrophil recovery time, resource utilization (e.g., hospitalization rates, antimicrobial therapies ...