KRAS这个靶点实在是太火了。

A research team led by MSK physician-scientist Dr. Piro Lito discovered that certain inhibitors can short-circuit the out-of-control signaling caused by mutations that fuel cancer growth. Each year, ...

RAS-family mutations are associated with numerous types of cancer. Now an MSK research team has identified a therapeutic approach that has shown promise in preclinical models. In a new study ...

These findings could pave the way for new treatment approaches for cancers driven by RAS mutations. Researchers at the ...

美国国立卫生研究院（NIH）的研究人员和他们的合作者发现了一种新的方式，RAS基因在癌症中通常发生突变，可能会推动肿瘤生长，而不是在细胞表面的信号传导中发挥众所周知的作用。根据2024年11月11日发表在《Nature Cancer》杂志上的一项研究，他们发现突变的RAS有助于启动一系列涉及特定核蛋白运输的事件，从而导致不受控制的肿瘤生长。

RHO GDIα and RHO GDIβ have been inhibited by siRNAs in breast cancer cell lines 137. GTP analogues, such as 6-thioGTP (SGTP), which is a metabolite of azathioprine, can directly inhibit RAS ...

Cancer cells cannot multiply without these supplies, and those with RAS mutations become uniquely capable of this type of scavenging, the study authors say. Led by researchers at NYU Grossman ...

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, ...

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, ...

By prioritising patient safety, health care providers can ensure that RAS procedures meet the highest standards of care ...

Immuneering Corporation (Nasdaq: IMRX), a clinical-stage oncology company seeking to develop and commercialize universal-RAS/RAF medicines for broad populations of cancer patients, today announced ...