2025年2月10日，加州大学Judy Van de Water团队在Molecular Psychiatry发表“Gestational autoantibody exposure impacts early brain development ...

本研究利用与临床相关的大鼠模型，深入探究妊娠期暴露于临床相关 MARA - AB 模式对出生后早期大脑基因表达和免疫信号分子的影响。在大鼠 PND2 时，其大脑神经发育过程与人类妊娠晚期相似，此时胎儿大脑在关键发育阶段易受外界因素影响，MARA - ABS 可通过胎盘进入胎儿体内，与靶蛋白相互作用，可能改变早期神经发育轨迹，影响细胞因子、趋化因子和生长因子等信号分子。

Fetal alcohol spectrum disorders (FASD), characterized by symptoms of cognitive decline, such as worsened memory and impaired ...

The first CF rat model, CFTR tm1sage (termed CFTR-/- or KO), was designed in collaboration with SAGE (now Horizon Discovery) and subsequently characterized at UAB and distributed to the CF community.

Van den Oever et al. have used a rat model to demonstrate that the link between re-exposure to preconditioned stimuli and heroin relapse could be explained by endocytosis of the AMPA receptor ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Researchers have identified brain circuits disrupted by prenatal alcohol exposure, which may explain the cognitive ...

Rodent study identifies a brain circuit that is disrupted by alcohol exposure during prenatal development and contributes to poor decision-making in adulthood.