presence of ssDNA signals that "something is wrong" and this also holds true for other phases of the cell cycle. In other words, whether ssDNA is created during replication, or outside of S phase ...

The mechanism of division in bacteria differs from that of eukaryotes, and the control of their cell cycle is also somewhat different, although again it is linked with DNA replication. Although ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of ...

The S phase checkpoint is a kinase signaling cascade that is activated in response to DNA damage or fork stalling during replication stress. Checkpoint activation results in the stabilization ... of ...

We investigate how RBPs influence viral infections and cellular stress responses ... viral genome replication, translation, and virion assembly. We use viral reverse genetics, CRISPR screening, and ...