Nature17 年
Challenges in tuberculosis drug research and development
and key antituberculous drugs, especially rifampin. It is very difficult, especially in resource-constrained settings, to accurately adjust dosages of the drugs in order to safely and effectively ...
Medscape5 天
Current Understanding of Hepatic and Intestinal OATP-mediated Drug-drug Interactions
Summarized are OATP1B1 drug substrates showing an increase in maximal plasma concentration (C max) and AUC due to interaction with the respective inhibitor (gemfibrozil, ciclosporin or rifampin).
The Lancet17 天
Representativeness and adverse event reporting in late-phase clinical trials for rifampin ...
We did a systematic review and meta-analysis of trials of treatment for rifampicin-susceptible tuberculosis to evaluate the ...
EurekAlert!2 年
RNAP and Rifampin (IMAGE)
Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks ...
Medscape1 个月
Current Understanding of Hepatic and Intestinal OATP-mediated Drug-drug Interactions
Summarized are OATP1B1 drug substrates showing an increase in maximal plasma concentration (C max) and AUC due to interaction with the respective inhibitor (gemfibrozil, ciclosporin or rifampin).