Aa Aa Aa It seems nearly impossible for a normal cell to become a cancer cell unless it inactivates the p53 network. Our current understanding of this network has come from diverse lines of ...

For example, MDM2 binds to TP53 mRNA, controlling the rate of translation, [24] and MDM2 regulates the levels of itself, MDM4 and p53. [23,25,26] The pivotal role of MDM2 and MDM4 in the control ...

Addressing the role of “genomic instability” in the evolution of p53 mutant tumors, we used a unique model that enables fluorescent tagging of cells that inactivate p53 well before tumors arise to ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer. This ...