A STAT5 dimer translocates to the nucleus and changes rates of transcription. STAT5 signaling is attenuated by the protein suppressors of cytokine signaling (SOCS)3 and protein inhibitor of ...

Members of the signal transducers and activators of transcription (Stat) family have been associated with oncogenesis; constitutively active forms of Stat3 and Stat5 can promote cell proliferation ...