In spite of this, Lin and colleagues 5 focused on the U6 snRNA, and adopted a metal specificity ... active site for the first step of pre-mRNA splicing. Phosphorothioate substitution can alter ...

The information content at the splice sites is very limited, because there is a serious problem in maintaining the fidelity of the reaction. "Early studies demonstrated that one of the RNAs--the small ...

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...

The paper is titled "Mutations in the U4 snRNA gene RNU4-2 cause one of the ... in a basic biological function of cells, ...