【导读】癌症免疫疗法的疗效依赖于足够数量的功能性免疫细胞。三阴性乳腺癌缺乏足够的免疫细胞浸润,因此,需要辅助治疗来增强抗肿瘤免疫力。然而,由于担心诱发全身免疫毒性,疗效的改善并不令人满意。在这项研究中,团队创建了一种由多肽-药物双亲化合物形成的阿贝西 ...
在这项最新研究中,研究团队发现了一种小分子——CT-1,它是隐丹参酮(CTS)的衍生物,能够有效抑制三阴性乳腺癌(TNBC)的生长,同时显著降低肿瘤组织中 N2 型肿瘤相关中性粒细胞(N2 型 TAN)的比例。
Novotech, the leading global full-service clinical Contract Research Organization (CRO), has released a comprehensive report analyzing the global clinical trial and drug development landscape for ...
【导读】C1QBP 在多种肿瘤中表达水平升高,从而促进肿瘤的增殖和转移,使其成为重要的治疗靶点。然而,迄今为止,尚未发现能够直接靶向并诱导 C1QBP 降解的药物。1月2日,南京医科大学研究团队在期刊《Clinical And ...
The increase in breast cancer rates among younger patients is occurring as the incidence of other early-onset cancers — ...
Anixa Biosciences CEO Amit Kumar discusses the biotech’s plans for advancing a breast cancer vaccine in 2025. The cancer ...
乳腺癌(BC)是全球最常见的癌症。乳腺癌发病率的上升,尤其是在年轻人群体中,已成为对女性健康的重大威胁。随着微生物检测技术的进步以及对肿瘤内微生物认识的加深,肿瘤内驻留细菌被认为是肿瘤微环境(TME)中的重要调节因子。这些微生物通常影响生理过程。这种 ...
目前,已有数百种用于乳腺癌的PDX和PDO模型被构建。然而,仍然缺乏最致命的乳腺癌亚型:内分泌抵抗性、治疗难治性和转移性乳腺癌。为了更好地了解不同乳腺癌亚型的治疗的敏感性和耐药性,有必要建立一个涵盖更大范围的晚期乳腺癌样本库。
Mersana shares Phase 1 data on Emi-Le for TNBC and details FDA's Fast Track status for XMT-1660 in advanced HER2-low breast ...
GEN-1184 is under clinical development by Genmab and currently in Phase II for Triple-Negative Breast Cancer (TNBC).
Katie and Lyndsay Cooper regularly monitored their breasts since discovering they had the BRCA1 mutation. Eventually, the ...
Scientists from CSIR-Central Drug Research Institute have discovered that targeting the enzyme acyl-CoA synthetase 4 (ACSL4) ...