This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic ...

In the current analysis, 814 consecutive patients underwent TPMT genotyping and received a 4-week cycle of mercaptopurine. Concluding that TPMT genotype has a significant effect on response to ...

Introduction The measurement of thiopurine methyl transferase (TPMT) can be used to identify patients at risk of marrow suppression from azathioprine. Across the medical specialities, there is no ...

Conclusion The data suggests that 6-MP enters red blood cells, where it undergoes methylation to 6-MeMP. The presence of 2OH6MP leads to a reduction in the rate of 6-MeMP production, most likely ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...

Five weeks previously, his methotrexate was tapered and he had begun taking azathioprine. The patient’s thiopurine S-methyltransferase (TPMT) activity level was normal prior to starting azathioprine.

Additionally, the collection includes two original research papers examining the genetic variability of the glucocorticoid pathway and the pharmacokinetics of ezetimibe, along with a research report ...

First author Rosalie M. Sterner, MD, Ph.D., Department of Laboratory Medicine and Pathology, Mayo Clinic in Rochester, notes, "Variants in the TPMT gene can result in decreased enzyme activity ...