This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic ...

In the current analysis, 814 consecutive patients underwent TPMT genotyping and received a 4-week cycle of mercaptopurine. Concluding that TPMT genotype has a significant effect on response to ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...

First author Rosalie M. Sterner, MD, Ph.D., Department of Laboratory Medicine and Pathology, Mayo Clinic in Rochester, notes, "Variants in the TPMT gene can result in decreased enzyme activity ...