Now, reporting in Science, Ito and colleagues show that cereblon (CRBN) is a primary teratogenic target of thalidomide. To identify this elusive target, the authors developed high-performance ...

When a drug binding-deficient mutant form of cereblon (CRBN YW/AA) is overexpressed in zebrafish (left) and chick (right) embryos, thalidomide-induced malformations of the fin or the wing are ...

Upon its 'reinvention', thalidomide was quickly applied to 'microenvironment-dependent' diseases such as multiple myeloma, yet its role in the solid tumor spectrum has not been validated.

Thalidomide survivor Lisa McManus has been critical of Australia's response Australia has fallen behind many other countries in its response to one of the world's worst pharmaceutical scandals ...