Thiopurines, such as azathioprine and mercaptopurine, are important medications used in the treatment of various conditions, including acute lymphoblastic leukemia (ALL) and inflammatory bowel ...

Differential responses to thiopurine drugs provide a concrete example of why this is true. Thiopurine drugs are used to treat acute lymphoblastic leukemia, inflammatory bowel disease, and organ ...

testing of thiopurine drugs, such as azathioprine. Six economic evaluations of testing were identified, which all recommended that TPMT testing is a cost-effective use of healthcare resources.

Thiopurine metabolism and thiopurine methyl transferase (TPMT) enzyme activity assay. Azathioprine (AZA) is converted into 6-mercaptopurine (6-MP), which can also be administered as a parent drug.

This study identified six economic evaluations, all of which used a decision-analytic approach and claimed that TPMT testing for patients prescribed thiopurine drugs was a cost-effective use of ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...