Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas nonreceptor tyrosine kinases and serine/threonine protein kinases function throughout ...

Protein phosphorylation is a covalent post-translational modification event that is essential for regulation and maintenance of most biological processes in eukaryotes 1. Conventionally ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Much of this control is via protein phosphorylation. MAP kinase is activated by dual phosphorylation at tyrosine and threonine residues, occurring in a TEY motif, catalyzed by a protein- ...

The membrane-associated tyrosine/threonine protein kinase 1 (PKMYT1) regulates cell cycle progression and maintains genomic integrity. If it is dysregulated, cells may enter mitosis prematurely, ...

Following protein concentration determination (by BCA assay), 5-10 μg of protein for the PTK chip (~1 μg for the STK) will be loaded per well of the PamChip along with standard kinase buffer (Supplied ...