we hypothesize that chronic oxidative stress is an important mechanism for glucose toxicity. Support for this hypothesis is found in the observations that high glucose concentrations increase ...

One approach to the early detection of kidney injury involves defining different biomarkers that rely on the mechanisms of toxicity of each drug or drug class. However, this approach can be ...

Performing multi-omics analyses using a single sample is challenging in toxicology studies. Now, researchers propose a new ...

The term "omics" refers to the study of the entirety of molecular mechanisms that happen inside an organism. With the advent ...

Digoxin toxicity causes hyperkalemia, or high potassium. The sodium/potassium ATPase pump normally causes sodium to leave cells and potassium to enter cells. Blocking this mechanism results in ...

The good news, however, is that it is possible to break the pattern of toxicity in your own life. It begins by recognizing the signs and learning to replace unhealthy coping mechanisms with ...

The mechanism of COX inhibition varies among NSAIDs ... variability in NSAID pharmacokinetics and toxicity.

A new human-relevant model for studying multi-system pharmacodynamics and toxicity for opioids and opioid overdose treatment ...