Thus, transcriptional control is dependent on the interactions of all the TFs and whether they attract RNA polymerase or block it from initiating transcription. Multiple TFs can accumulate ...

该研究表明，使用特定的抑制剂（如AZD4573）靶向CDK9可以显著损害palbociclib敏感性和耐药的LTED细胞系的活力，以及患者来源的类器官（PDO）和PDX模型。

Therefore, we set out to investigate alternative balancing mechanisms, whose induction must occur faster than transcriptional regulation. An unanswered, but intriguing question, concerns the ...

Researchers have revealed how the folding and movement of DNA that brings distant regions closer together is linked to bursts ...