a transmembrane ligand expressed on osteoblasts/stromal cells, that binds to RANK, a transmembrane receptor on hemopoietic osteoclast precursor cells. The interaction of RANK and RANKL initiates a ...

Seven-transmembrane segment ... suggest that MIP-1α binding to CCR5 proteoliposomes is highly dependent upon ligand concentration and cooperativity. Because of the complex nature of the binding ...

The common understanding of how to activate an aGPCR is that a ligand from outside the cell ... that remains attached to the transmembrane region. When the TA is separated, it can move and ...