However, these classical models of receptor/G protein coupling may be oversimplified ... these could be association of the extracellular domains, transmembrane domains, and/or C-terminal tail.

New research from the University of Chicago combines two powerful imaging techniques to study the complete structure of a ...

Transmembrane proteins (TPs) are proteins that traverse both the intracellular and extracellular environments and are embedded in the cell membrane. The transmembrane area, which interacts ...

More information: Shian Liu et al, Architecture and activation of single-pass transmembrane receptor guanylyl cyclase, Nature Structural & Molecular Biology (2024). DOI: 10.1038/s41594-024-01426-z ...

VLPs can display membrane proteins in their full natural conformation on the surface of virus-like particles, resulting in full-length transmembrane proteins suitable for immunization and antibody ...

The Falke group is currently investigating the molecular mechanisms of on-off switching of components within the chemosensory array, especially the mechanisms by which transmembrane receptors bind ...

Adhesion G protein-coupled receptors (aGPCRs ... how its long and complex extracellular region interacts with the transmembrane region embedded in the cell surface. The different positions ...

Most drugs target membrane proteins, accessible on the surface of cells, to alter the transport of ions and molecules and the transduction of cellular signals. The Diver lab explores the biological ...

“The structure reveals an unusual binding mode, where two copies of FFA are bound at distinct pockets: one at the canonical receptor site within the transmembrane ... of proteins to be seen ...