Extraembryonic trophoblast lineages constitute the placenta, and are essential for individual development. In human early embryo development, these cells can be generated from totipotent blastomeres.

Conventional human pluripotent stem cells at the primed pluripotent state are capable of generating all the embryonic lineages. However, their ...

However, cell type-specific enhancers and transcription factors (TFs), and the mechanisms underlying the maintenance and differentiation of trophoblast stem cell (TSC) populations in the human ...