E6 associates with p53 and targets it for rapid degradation mediated by the ubiquitin ligase E6-associated protein (E6-AP), which does not recognize the free tumor suppressor. Inactivation of the ...

Here we describe the generation and characterization of green fluorescent protein (GFP)-based substrates that allow rapid quantification of ubiquitin–proteasome-dependent proteolysis in living ...

However, the relationship between the enzymes and their corresponding substrates has not yet been well established, and the development of technology that comprehensively analyzes the ubiquitin system ...

Arcus Biosciences Inc. has synthesized new E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.

Scientists at Inventisbio Co. Ltd. and Inventisbio LLC have divulged E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.