E6 associates with p53 and targets it for rapid degradation mediated by the ubiquitin ligase E6-associated protein (E6-AP), which does not recognize the free tumor suppressor. Inactivation of the ...
A recent study published in eLife has uncovered a crucial mechanism in cellular material management: endosome maturation. The ...
However, the relationship between the enzymes and their corresponding substrates has not yet been well established, and the development of technology that comprehensively analyzes the ubiquitin system ...
Here we describe the generation and characterization of green fluorescent protein (GFP)-based substrates that allow rapid quantification of ubiquitin–proteasome-dependent proteolysis in living ...
My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases ... Central to our research efforts, we employ ...
The tag is a small protein called ubiquitin, which effectively gets fired at the disease-causing protein like a bullet. In ...
Arcus Biosciences Inc. has synthesized new E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.
Scientists at Inventisbio Co. Ltd. and Inventisbio LLC have divulged E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.