The release of neurotransmitters from synaptic vesicles in response to stimulation is crucial for information transfer between neurons. Before exocytosis takes place synaptic vesicles must be ...

The left electron microscope image shows "exocytosis." Parts of two nerve ... The top nerve cell is filled with tiny round bubbles known as vesicles. One of those vesicles, which appears like ...

Our team has conducted the first genome-wide CRISPR screens to systematically identify new regulators of regulated exocytosis—a type of vesicle fusion—in mammalian cells. These screens revealed a ...

"Until our collaborative study, exocyst was understood to recognize and possibly tether secretory vesicles to the cell membrane, prior to exocytosis. In this study, we reveal biophysical studies ...

More information: Chanwoo Lee et al, Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion, Nature Structural & Molecular Biology (2024). DOI: 10.1038/s41594-024 ...