As a result, “a lot of research is turning toward pathway-targeted ... and metabolism are linked, said Vogelstein, whose group has worked on the genetics of colorectal cancer for over two ...

Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274. An adaptation of the Vogelstein adenoma:carcinoma sequence. The acquisition of a mutation (or 'hit') in a stem cell within a crypt ...