lose its ability to regulate signalling and lose its functions as a tumour suppressor. Both types of change in Wnt signalling have been linked to cancer. Therefore, a great deal of effort is being ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Several types of human cancer, particularly colon cancer, have been linked to the Wnt signaling pathway ... that dimerization may have a role in the function of these proteins.