In metazoan, growth factors are also needed to relieve the inhibition of mTORC1 by PRAS40. In earlier work, we had determined the crystal structure of truncated mTOR containing the kinase domain and ...

Unexpectedly, rapamycin-mediated inhibition of mTOR caused an increase ... level through at least two independent mechanisms. mTOR was shown to limit the production of pro-inflammatory cytokines ...

indicating that it is not a cell-intrinsic mechanism but delivery of rapamycin to tumour cells that is impaired in some patients. As mTOR inhibitors can inhibit a negative feedback loop that ...

Published in the Proceedings of the National Academy of Sciences, the study "Unconventional Mechanism of Action and ... with drug binding. However, mTOR, the drug target, is not mutated when ...

Abstract Title: Mechanism of action of gedatolisib in combination with fulvestrant and/or palbociclib in estrogen receptor ...

The company's lead therapeutic candidate is gedatolisib, a potent, pan-PI3K and mTOR inhibitor. Its mechanism of action and pharmacokinetic properties are highly differentiated from other currently ...