IBS was assessed using the Rome III criteria and the IBS severity score. Epithelial barrier integrity was evaluated by determining the paracellular permeability of biopsies mounted in Ussing chambers ...

uk-erlangen.de Objectives Pathologic fibroblast activation drives fibrosis of the skin and internal organs in patients with systemic sclerosis (SSc). β-catenin is an integral part of adherens ...

The US Food and Drug Administration has granted orphan drug designation (ODD) to Tempest Therapeutics' oral, selective ...

The US Food and Drug Administration has granted orphan drug designation (ODD) to Tempest Therapeutics’ oral, selective peroxisome proliferator-activated receptor alpha (PPAR-α) antagonist amezalpat ...

我们的肠道中生活着大量的微生物，它们与我们的健康和疾病密切相关，不仅影响肠胃，还牵动着其它内脏器官的健康。过去，人们总认为胃里是无菌的，因为那里的酸性很强、黏液层很厚，胃还在不断蠕动和排空，好像不适合微生物生存。然而，众所周知，幽门螺旋杆菌就能够在这 ...

The US Food and Drug Administration has granted orphan drug designation (ODD) to Tempest Therapeutics' oral, selective peroxisome proliferator-activated receptor alpha (PPAR-α) antagonist ...

The gut microbiome, or the community of microorganisms residing in the gastrointestinal tract, has emerged as an important ...

5 In short, inactive JAK enzymes are loosely attached to the cytoplasmic domains of specific cytokine receptors (including interferon (IFN)-α/β/γ, interleukin (IL)-2, IL-4, IL-6, IL-10, and IL-12).

The pelviperineal organs of the female reproductive tract form an essential cornerstone of human procreation. The system comprises the ectodermal external genitalia, the Müllerian upper-vaginal, ...