ACE2 and TMPRSS2 were not only coexpressed in lung AT2 cells and oesophageal upper epithelial and gland cells but also highly expressed in absorptive enterocytes from the ileum and colon. Additionally ...

The SARS-CoV-2 spike (S) protein mediates its attachment and entry into host cells by binding to the angiotensin converting enzyme (ACE2) receptor. The expression of ACE2, which is present at high ...

Tofacitinib, approved to treat ulcerative colitis, reversed the increased ACE2 expression on lung, intestinal, and immune cells, thus reducing susceptibility to viral invasion." Janus kinase (JAK ...

The study, led by immunologist Declan McCole at the University of California, Riverside, shows that a loss-of-function variant in the phosphatase gene PTPN2, commonly associated with autoimmune ...

Tofacitinib, approved to treat ulcerative colitis, reversed the increased ACE2 expression on lung, intestinal, and immune cells, thus reducing susceptibility to viral invasion." Janus kinase (JAK ...

Recent studies have found that CD209 (DC-SIGN) might be a potential binding receptor for SARS-CoV-2 in addition to the well-known receptor ACE2 ... The CD209 expression declined dramatically in ...

This prospective case-control study included 85 patients with lung involvement related to the COVID-19 virus and a group of ...