Conclusion In the longest DMOAD trial reported to date, sprifermin maintained long-term structural modification of articular cartilage over 3.5 years post-treatment. Potential translation to clinical ...

Use of bisphosphonates, however, might be limited by gastrointestinal side effects or by the development of osteonecrosis of the jaw. Although ... the role of RANKL in cartilage biology.

Gli1+ cells at the superficial layers of the condylar cartilage increased at 1 month and decreased at 3 months post-induction. This behavior is similar to that of Gli1+ cells in the upper layers of ...

The top-down calcification process started with spherical mineral particle formation in the joint surface during early-stage OA (OA-E), followed by fibre formation and densely packed material ...

The clinical treatment of cartilage defects is a significant challenge (Gomez et al., 2020; Mardones et al., 2020; Pattappa et al., 2020), as current methods do not provide an ideal graft for ...

Objective To (1) develop and evaluate a machine learning model incorporating gait and physical activity to predict medial tibiofemoral cartilage worsening over 2 years in individuals without advanced ...

We present a case of a 56-year-old woman with a history of invasive ductal cell carcinoma of the right breast, 10 years in remission, presenting with a 6-month history of symptoms typical of ...

Introduction Temporomandibular disorders (TMDs) are musculoskeletal disorders characterised by jaw pain and typically temporomandibular joint limitations. Resistance training (RT) has been shown to be ...

The solute carrier family 26 member 2 (SLC26A2) is another candidate gene for clubfoot, implicated in disorders of cartilage and bone development. SLC26A2 transports sulfate ions involved in cartilage ...

The presence of knee crepitus was associated with a more than threefold increased odds of radiographic OA diagnosis. Knee crepitus is also associated with the presence of osteophytes, cartilage damage ...

Bianca Censori made her jaw-dropping debut at the 2025 Grammys alongside Kanye West in dramatic fashion. All eyes were on the couple — for obvious reasons — as they made a surprise appearance ...