After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do ...

A new study describes a molecular mechanism that could drive the design of strategies to eliminate senescent cells in cancer ...

The study is based on the analysis of human senescent cells in a specific tumor model — melanoma, which affects skin cells known as melanocytes — and, more specifically, melanocytes exposed to ...

BCL-2 antagonists will probably begin their commercial lives as products that disable the anti-apoptotic machinery and restore chemosensitivity, pairing favourably with conventional cytotoxic ...

“This is the first time that the molecular basis for the anti-apoptotic adaptation of BCL ... and whether it is mediated by the interaction of the BCL-2 family proteins themselves or others.

Neutrophil survival is governed by both pro-apoptotic and anti-apoptotic factors in the intracellular and extracellular environment ... endotoxins increase lifespan partly through upregulation of ...

Novel monoclonal antibodies and agents directed to inhibit microenvironment survival signals, antigenic stimulation through the BCR and deregulated apoptotic pathways are represented. Bcl-2 ...