Here authors show via B-cell specific genomic deletion mouse models that the transcriptional repressor capicua (CIC) and its binding partner, ataxin-1-like (ATXN1L), differentially regulate the ...

However, it is not well understood how cells survive when such TFs are lost, for example in cancer. PU.1 is an essential TF for myeloid fate, and mice with downregulated PU.1 levels develop acute ...

We show that DNA-PK acts as a pattern recognition receptor, binding cytoplasmic DNA and triggering the transcription of type I interferon (IFN), cytokine and chemokine genes in a manner dependent on ...