We also used agonists and antagonists of the MAPK and NF-κB pathways to investigate the possible pathway involved. Peripheral blood mononuclear cells from one healthy donor were also used for ...

Cordenonsi, M. et al. Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation. Science 315 , 840–843 (2007). Article CAS Google Scholar ...

【导读】小细胞肺癌（SCLC）是一种侵袭性极强的神经内分泌肿瘤，预后极差。目前，能够促进小细胞肺癌免疫疗法的特异性肿瘤抗原仍未找到。2025年1月13日，中国医学科学院肿瘤医院肿瘤内科王洁教授团队在期刊《eBioMedicine》上发表了题为“ATA ...

The senescence-associated markers p16, p21, p53 and beta galactosidase were induced upon drug treatment ... with increased insulin-stimulated phosphorylation of IR, Akt, and MAPK. Together, these data ...

近年来，多项研究表明关黄柏及其主要活性成分在诱导肿瘤细胞自噬与凋亡方面具有良好的活性。木兰碱、四氢巴马汀及黄柏碱等均能通过调控自噬与凋亡信号蛋白表达而发挥诱导细胞凋亡作用，抑制恶性肿瘤的发展与转移。

Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and ...

The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer.

Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent cell cycle delay. These studies highlight the distinct effects ...

1 Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands 2 Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands ...

Structural, functional, and molecular‐level changes in the aging heart are influenced by a dynamic interplay between immune signaling and cellular metabolism that is referred to as immunometabolism.

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...