Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells with the morphology of plasma cells. pDCs produce massive amounts of type I interferon (IFN-I), which was originally found ...

To address these limitations of DC as immunotherapeutic agent, we have developed a polymeric nanocomplex incorporating (1) oncolytic adenovirus (oAd) co-expressing interleukin (IL)-12 and ...

Given the central role of dendritic cells (DCs) in initiating and shaping antiviral T cell responses ... In this respect, the concentration of serum HBsAg might be a predictive factor for the ...

cost offsets and/or cost drivers of PEG compared with non-PEGylated drug versions were selected for review. Once literature reviews and studies not yielding PEG versus non-PEG results were ...

mimicking living cell functions It creates transport channels in synthetic cells to enhance drug delivery Synthetic cells can replicate living cells' behavior, offering new medical treatment ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling ...

CHO cells have become essential tools in modern medicine, serving as the "living factories" that produce more than half of today's top-selling protein-based drugs, including therapies for cancer ...

We used retriever to extract transcriptional drug response signatures of triple-negative breast cancer (TNBC) cell lines and combined these with a single-cell RNA-seq breast cancer atlas to predict ...

Genetic tweak optimizes drug-making cells by blocking buildup of toxic byproduct New discovery about lactic acid metabolism in cells resolves a decades-old challenge in biomanufacturing Date ...

Feb. 10, 2025 — Evolution is traditionally associated with a process of increasing complexity and gaining new genes. However, the explosion of the genomic era shows that gene loss and ...